Domain organization of MA3 domain-containing proteins in Homo sapiens and Arabidopsis thaliana. The domain organization of eIF4G and PDCD4 proteins is shown for H. sapiens (Hs) and A. thaliana (At). For eIF4G, the interaction domains for the translation initiation factors eIF4E, eIF4A, eIF4B, eIF3, as well as the poly(A)-binding protein (PABP) and Mnk kinase are shown. The MA3 domains are shown in blue for eIF4G and for the animal and plant PDCD4 proteins. MAT5-8 comprise the PDCD4 gene family in A. thaliana. eIF4G (MAT1, At3g60240), eIFiso4G1 (MAT2, At5g57870), eIFiso4G2 (MAT3, At2g24050), MAT4 (At4g30680), MAT5 (At4g24800), MAT6 (At5g63190), MAT7 (At3g48390), MAT8 (At1g22730).
Cheng et al. BMC Evolutionary Biology 2013 13:199 doi:10.1186/1471-2148-13-199