Figure 7.

Arginine, ornithine, and polyamine synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: glutamate; II: N-acetylglutamate; III: N-acetylglutamyl-phosphate; IV: N-acetyl-glutamate semialdehyde; V: N-acetylornithine; VI: ornithine; VII: carbamoyl-phosphate; VIII: citruline; IX: aspartate; X: arginino succinate; XI: arginine; XII: fumarate; XIII: urea; XIV: agmatine; XV: putrescine; XVI: S-adenosylmethionine; XVII: S-adenosylmethioninamine; XVIII: spermidine; XIX: spermine. Enzymes – 2.1.3.3: ornithine carbamoyltransferase; 6.3.4.5: argininosuccinate synthase; 4.3.2.1: argininosuccinate lyase; 3.5.3.1: arginase; 4.1.1.17: ornithine decarboxylase; 3.5.1.14: aminoacylase; 3.5.1.16: acetylornithine deacetylase; 2.3.1.35: glutamate N-acetyltransferase; 2.6.1.11: acetylornithine aminotransferase; 1.2.1.38: N-acetyl-gamma-glutamyl-phosphate reductase; 2.7.2.8: acetylglutamate kinase; 2.3.1.1: amino-acid N-acetyltransferase; 3.5.3.11: agmatinase; 4.1.1.19: arginine decarboxylase; 4.1.1.50: adenosylmethionine decarboxylase; 2.5.1.16: spermidine synthase. Abbreviations as for Figure 1.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
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