Phenylalanine, tyrosine, and tryptophan synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: D-erythrose 4-phosphate; II: phosphoenolpyruvate; III: 7-phosphate-2-dehydro-3-deoxy-D-arabinoheptonate; IV: 3-dehydroquinate; V: 3-dehydroshikimate; VI: shikimate; VII: shikimate 3-phosphate; VIII: 5-O-(1-carboxyvinyl)-3-phosphoshikimate; IX: chorismate; X: anthranilate; XI: N-(5-Phospho-D-ribosyl)anthranilate; XII: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate; XIII: indoleglycerol phosphate; XIV: indole; XV: tryptophan; XVI: prephenate; XVII: arogenate; XVIII: phenylpyruvate; XIX: 4-hydroxyphenylpyruvate; XX: tyrosine; XXI: phenylalanine. Enzymes – 22.214.171.124: 3-deoxy-7-phosphoheptulonate synthase; 126.96.36.199: 3-dehydroquinate synthase; 188.8.131.52: 3-dehydroquinate dehydratase I; 184.108.40.206: shikimate dehydrogenase; 220.127.116.11: shikimate kinase; 18.104.22.168: 3-phosphoshikimate 1-carboxyvinyltransferase; 22.214.171.124: chorismate synthase; 126.96.36.199: anthranilate synthase; 188.8.131.52: anthranilate phosphoribosyltransferase; 184.108.40.206: phosphoribosylanthranilate isomerase; 220.127.116.11: indoleglycerol phosphate synthetase; 18.104.22.168a/b: tryptophan synthase alpha (a) and beta (b) subunits; 22.214.171.124/126.96.36.199: bifunctional prephenate dehydratase/chorismate mutase; 188.8.131.52: aromatic amino acid aminotransferase; 184.108.40.206: prephenate dehydrogenase (NADP+); 220.127.116.11: aspartate aminotransferase; 18.104.22.168: tyrosine aminotransferase; 22.214.171.124: histidinol-phosphate aminotransferase; 126.96.36.199: phenylalanine-4-hydroxylase. Abbreviations as for Figure 1.
Alves et al. BMC Evolutionary Biology 2013 13:190 doi:10.1186/1471-2148-13-190