Phenylalanine, tyrosine, and tryptophan synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: D-erythrose 4-phosphate; II: phosphoenolpyruvate; III: 7-phosphate-2-dehydro-3-deoxy-D-arabinoheptonate; IV: 3-dehydroquinate; V: 3-dehydroshikimate; VI: shikimate; VII: shikimate 3-phosphate; VIII: 5-O-(1-carboxyvinyl)-3-phosphoshikimate; IX: chorismate; X: anthranilate; XI: N-(5-Phospho-D-ribosyl)anthranilate; XII: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate; XIII: indoleglycerol phosphate; XIV: indole; XV: tryptophan; XVI: prephenate; XVII: arogenate; XVIII: phenylpyruvate; XIX: 4-hydroxyphenylpyruvate; XX: tyrosine; XXI: phenylalanine. Enzymes – 184.108.40.206: 3-deoxy-7-phosphoheptulonate synthase; 220.127.116.11: 3-dehydroquinate synthase; 18.104.22.168: 3-dehydroquinate dehydratase I; 22.214.171.124: shikimate dehydrogenase; 126.96.36.199: shikimate kinase; 188.8.131.52: 3-phosphoshikimate 1-carboxyvinyltransferase; 184.108.40.206: chorismate synthase; 220.127.116.11: anthranilate synthase; 18.104.22.168: anthranilate phosphoribosyltransferase; 22.214.171.124: phosphoribosylanthranilate isomerase; 126.96.36.199: indoleglycerol phosphate synthetase; 188.8.131.52a/b: tryptophan synthase alpha (a) and beta (b) subunits; 184.108.40.206/220.127.116.11: bifunctional prephenate dehydratase/chorismate mutase; 18.104.22.168: aromatic amino acid aminotransferase; 22.214.171.124: prephenate dehydrogenase (NADP+); 126.96.36.199: aspartate aminotransferase; 188.8.131.52: tyrosine aminotransferase; 184.108.40.206: histidinol-phosphate aminotransferase; 220.127.116.11: phenylalanine-4-hydroxylase. Abbreviations as for Figure 1.
Alves et al. BMC Evolutionary Biology 2013 13:190 doi:10.1186/1471-2148-13-190