Figure 5.

Phenylalanine, tyrosine, and tryptophan synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: D-erythrose 4-phosphate; II: phosphoenolpyruvate; III: 7-phosphate-2-dehydro-3-deoxy-D-arabinoheptonate; IV: 3-dehydroquinate; V: 3-dehydroshikimate; VI: shikimate; VII: shikimate 3-phosphate; VIII: 5-O-(1-carboxyvinyl)-3-phosphoshikimate; IX: chorismate; X: anthranilate; XI: N-(5-Phospho-D-ribosyl)anthranilate; XII: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate; XIII: indoleglycerol phosphate; XIV: indole; XV: tryptophan; XVI: prephenate; XVII: arogenate; XVIII: phenylpyruvate; XIX: 4-hydroxyphenylpyruvate; XX: tyrosine; XXI: phenylalanine. Enzymes – 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase; 4.2.3.4: 3-dehydroquinate synthase; 4.2.1.10: 3-dehydroquinate dehydratase I; 1.1.1.25: shikimate dehydrogenase; 2.7.1.71: shikimate kinase; 2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase; 4.2.3.5: chorismate synthase; 4.1.3.27: anthranilate synthase; 2.4.2.18: anthranilate phosphoribosyltransferase; 5.3.1.24: phosphoribosylanthranilate isomerase; 4.1.1.48: indoleglycerol phosphate synthetase; 4.2.1.20a/b: tryptophan synthase alpha (a) and beta (b) subunits; 4.2.1.51/5.4.99.5: bifunctional prephenate dehydratase/chorismate mutase; 2.6.1.57: aromatic amino acid aminotransferase; 1.3.1.13: prephenate dehydrogenase (NADP+); 2.6.1.1: aspartate aminotransferase; 2.6.1.5: tyrosine aminotransferase; 2.6.1.9: histidinol-phosphate aminotransferase; 1.14.16.1: phenylalanine-4-hydroxylase. Abbreviations as for Figure 1.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
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