Figure 5.

Phenylalanine, tyrosine, and tryptophan synthesis pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: D-erythrose 4-phosphate; II: phosphoenolpyruvate; III: 7-phosphate-2-dehydro-3-deoxy-D-arabinoheptonate; IV: 3-dehydroquinate; V: 3-dehydroshikimate; VI: shikimate; VII: shikimate 3-phosphate; VIII: 5-O-(1-carboxyvinyl)-3-phosphoshikimate; IX: chorismate; X: anthranilate; XI: N-(5-Phospho-D-ribosyl)anthranilate; XII: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate; XIII: indoleglycerol phosphate; XIV: indole; XV: tryptophan; XVI: prephenate; XVII: arogenate; XVIII: phenylpyruvate; XIX: 4-hydroxyphenylpyruvate; XX: tyrosine; XXI: phenylalanine. Enzymes – 3-deoxy-7-phosphoheptulonate synthase; 3-dehydroquinate synthase; 3-dehydroquinate dehydratase I; shikimate dehydrogenase; shikimate kinase; 3-phosphoshikimate 1-carboxyvinyltransferase; chorismate synthase; anthranilate synthase; anthranilate phosphoribosyltransferase; phosphoribosylanthranilate isomerase; indoleglycerol phosphate synthetase; tryptophan synthase alpha (a) and beta (b) subunits; bifunctional prephenate dehydratase/chorismate mutase; aromatic amino acid aminotransferase; prephenate dehydrogenase (NADP+); aspartate aminotransferase; tyrosine aminotransferase; histidinol-phosphate aminotransferase; phenylalanine-4-hydroxylase. Abbreviations as for Figure 1.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
Download authors' original image