Figure 2.

Cysteine and methionine synthesis and interconversion pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: L-serine; II: O-acetyl-serine; III: cysteine; IV: cystathionine; V: homocysteine; VI: methionine; VII: S-adenosyl-methionine; VIII: S-adenosyl-homocysteine; IX: succinyl-homoserine; X: homoserine; XI: aspartate 4-semialdehyde. Enzymes – serine O-acetyltransferase; cysteine synthase; cystathionine gamma-lyase; cystathionine beta-lyase; 2.1.1.x:, homocysteine S-methyltransferase,, 5-methyltetrahydrofolate–homocysteine methyltransferase,, 5-methyltetrahydropteroyltriglutamate–homocysteine methyltransferase; S-adenosyl-methionine synthetase; DNA (cytosine-5-)-methyltransferase; adenosylhomocysteinase; cystathionine beta-synthase; cystathionine gamma-synthase; homoserine O-succinyltransferase; homoserine dehydrogenase. Abbreviations as for Figure 1.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
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