Figure 2.

Cysteine and methionine synthesis and interconversion pathway. Enzymes surrounded by a thick gray box were shown to be horizontally transferred from Bacteria (see main text). Metabolites – I: L-serine; II: O-acetyl-serine; III: cysteine; IV: cystathionine; V: homocysteine; VI: methionine; VII: S-adenosyl-methionine; VIII: S-adenosyl-homocysteine; IX: succinyl-homoserine; X: homoserine; XI: aspartate 4-semialdehyde. Enzymes – 2.3.1.30: serine O-acetyltransferase; 2.5.1.47: cysteine synthase; 4.4.1.1: cystathionine gamma-lyase; 4.4.1.8: cystathionine beta-lyase; 2.1.1.x: 2.1.1.10, homocysteine S-methyltransferase, 2.1.1.13, 5-methyltetrahydrofolate–homocysteine methyltransferase, 2.1.1.14, 5-methyltetrahydropteroyltriglutamate–homocysteine methyltransferase; 2.5.1.6: S-adenosyl-methionine synthetase; 2.1.1.37: DNA (cytosine-5-)-methyltransferase; 3.3.1.1: adenosylhomocysteinase; 4.2.1.22: cystathionine beta-synthase; 2.5.1.48: cystathionine gamma-synthase; 2.3.1.46: homoserine O-succinyltransferase; 1.1.1.3: homoserine dehydrogenase. Abbreviations as for Figure 1.

Alves et al. BMC Evolutionary Biology 2013 13:190   doi:10.1186/1471-2148-13-190
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