Additional file 1: Figure S1.

Importance of amino acid sites in the coevolutionary netoworks of GroES (a to c) and GroEL (d to f). We used centrality measures to determine how many coevolution links did each of the amino acid sites detected using CAPS have with the other sites in the protein. We used three main centrality measures, including Betweenness, closeness and degree for the networks of GroES (a to c) and GroEL (d to f). Respectively. In these networks, amino acid sites are represented using the three-letter amino acid codes followed by the position of the amino acid in the three-dimensional structure of the GroESL protein complex (PDB ID: 1AON, MMDB ID: 47936). The diameter of the circles is proportional to the centrality of that amino acid site in the network.

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Ruiz-Gonz├ílez and Fares BMC Evolutionary Biology 2013 13:156   doi:10.1186/1471-2148-13-156