Distribution of groups of coevolving sites within the three domains of crystal structure of GroEL (1AON.pdb). We compared these distributions using a dimer GroEL2-GroES2. The groups of bacteria represented are Actinobacteria (a) Bacteroidetes (b) Cyanobacteria (c) Spirochaetes (d) Firmicutes (e) and Proteobacteria (f). Sites under coevolution are highlighted as solid spheres, with those belonging to the same group colour-coded. Sites falling within the apical, intermediate and equatorial domains are coded with the colours blue, yellow and red, respectively.
Ruiz-González and Fares BMC Evolutionary Biology 2013 13:156 doi:10.1186/1471-2148-13-156