Putative evolutionary history of MYH14 and miR-499 in the fish lineage. The common ancestor of amniotes and fish had a single miR-499 containing MYH14. Neoteleostei-specific whole genome duplication formed two sets of MYH14/miR-499 pairs. In the zebrafish lineage, additional tandem duplication resulted in three MYH14/miR-499 pairs. In torafugu, green spotted puffer, and tilapia, redundancy in miR-499 caused the deletion of one of the two miR-499 paralogs. In the stickleback and Atlantic cod lineage, an additional gene loss occurred in one of the two MYH14 paralogs and loss of the remaining MYH14 gene resulted in its complete elimination from the medaka genome.
Bhuiyan et al. BMC Evolutionary Biology 2013 13:142 doi:10.1186/1471-2148-13-142