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Hypervariable antigen genes in malaria have ancient roots

Martine M Zilversmit1234*, Ella K Chase3, Donald S Chen2, Philip Awadalla4, Karen P Day2 and Gil McVean35

Author Affiliations

1 National Institute of Allergy of Infectious Disease, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA

2 Department of Microbiology, NYU Langone Medical Center, 341 East 25th Street, New York, NY 10010, USA

3 Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK

4 CHU Sainte-Justine Centre de Recherche, Universit de Montral, 3175 Cote-Ste-Catherine, Montreal, QC, H3T 1C5, Canada

5 Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK

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BMC Evolutionary Biology 2013, 13:110  doi:10.1186/1471-2148-13-110

Published: 31 May 2013

Additional files

Additional file 1:

Hidden Markov-Model to Recover Mosaic Recombination. A PDF file showing the full hidden Markov model, in detail, and added information on tests using simulated data.

Format: PDF Size: 378KB Download file

This file can be viewed with: Adobe Acrobat Reader

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Additional file 2:

Analysis and Results of Core Motifs and Conserved Peptides. An MS Word document describing and summarizing the analysis of core motifs and conserved peptides between P. reichenowi and P. falciparum.

Format: DOCX Size: 162KB Download file

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Additional file 3:

Core motifs (conserved motif classification) and genes with each one. Core motifs ordered alphabetically, with the listing of all loci with that motif.

Format: TXT Size: 8KB Download file

Open Data

Additional file 4:

Alignments of conserved peptides. An MS Word document showing all alignments between P. reichenowi and P. falciparum for conserved peptides.

Format: DOCX Size: 88KB Download file

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Additional file 5:

Plasmodium reichenowi DBLα Domains. A tab delimited file containing curated Plasmodium reichenowi DBLα domains used in this research.

Format: TXT Size: 16KB Download file

Open Data