Phylogenetic and Pfam domain analyses of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2. Numbers above branches show bootstrap values for maximum likelihood and distance analyses respectively. Asterisks indicate values lower than 50%. Other bootstrap values below 50% in both methods are not shown. Red: tunicates; green: Plantae; blue: cyanobacteria; pink: other plastid-containing eukaryotes. Three identical tandem domains (Ion transport protein N-terminal/Ion transport protein/Cyclic nucleotide-binding domain) are restricted to animals and algae. Several animal and algal sequences contain only one or two domains, suggestive of potential loss over time.
Ni et al. BMC Evolutionary Biology 2012 12:83 doi:10.1186/1471-2148-12-83