Positively selected sites in PTP EX subclade. In the alignment, PTP EX sequences are represented with the same amino acid numbering to facilitate comparisons. Structural motifs identified in Vertebrate PTPs are indicated. Variable regions α1/β1 loop, α5-loop-α6 and sites involved in substrate specificity (noted S) are mentioned. Stars indicate sites significantly shown to evolve under positive selection.
Serbielle et al. BMC Evolutionary Biology 2012 12:253 doi:10.1186/1471-2148-12-253