Figure 3.

Amino acid sequences and the variability in the exon 2 of bear DQBs. (A - B) Gray boxes indicate positions of the putative peptide binding residues (PBRs) deduced from the amino acid position in the human DR molecule, and the numbers across the sequence correspond to amino acid positions based on the chain of the human DR structure [40]. A filled asterisk represents the putative site under balancing selection identified by both of PAML and OmegaMap programs, while an open asterisk is that by the OmegaMap only. (A) Alignment of the predicted amino acid sequence translated from nucleotides of MHC DQB variants in the Japanese black bear. Dots indicate identity with amino acids of Urth-DQB*01. Urth-DQB*32 includes the putative premature stop codon within the sequence. (B) The variability level at amino acid residues among DQB variants of the Japanese black bear. The variability level was estimated by a Wu-Kabat plot [85]

Yasukochi et al. BMC Evolutionary Biology 2012 12:230   doi:10.1186/1471-2148-12-230
Download authors' original image