Amino acid sequences of MHC alleles in the Scandinavian brown bear. Positions in the alignment correspond to Human Leukocyte Antigen (HLA, after Reche & Reinherz, 2003). Dots mark identity to the reference sequence. The putative Antigen Binding Sites consensus positions (HLA-A, HLA-B and HLA-C for MHC class I 2nd exon alleles, HLA-DRβ for MHC class II DRB 2nd exon, HLA-DQα for MHC class II DQA 2nd exon and HLA-DQβ for MHC class II DQB 2nd exon; after Reche & Reinherz, 2003) are marked with ‘+’. Positively selected amino acid sites identified by the Bayes empirical Bayes procedure are shaded (** - posterior probability > 99%, * - posterior probability >95%).
Kuduk et al. BMC Evolutionary Biology 2012 12:197 doi:10.1186/1471-2148-12-197