Additional file 1.

A single PDF file containing supplementary Tables S1–S5. Table S1 lists the results of the paired tests comparing the evolutionary rates of each gene with those of its direct downstream targets while controlling for a number of correlates of rates of evolution. Table S2 lists the Mann–Whitney tests comparing the evolutionary rates of genes occupying extreme upstream and downstream positions while controlling for a number of correlates of rates of evolution. Table S3 lists the partial correlation analyses contrasting the association between upstream/downstream position of genes and their rates of evolution while controlling for a number of correlates of rates of evolution. Table S4 lists the partial correlation analyses contrasting the association between rates of evolution and measures of hierarchical position while controlling for a number of correlates of rates of evolution. Table S5 lists the ω values for genes involved in the mammalian Ras signaling pathway.

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Alvarez-Ponce BMC Evolutionary Biology 2012 12:192   doi:10.1186/1471-2148-12-192