Joint analysis of the effects of both core size (small or large) and expression level (low or high) on the relationship between ω = dN/dS and RSA. Only the fitted lines are shown. Surprisingly, for low-expression genes, small-core proteins evolve faster than larger-core proteins. This relationship is reversed in a larger dataset obtained with less-stringent criteria (see text).
Scherrer et al. BMC Evolutionary Biology 2012 12:179 doi:10.1186/1471-2148-12-179