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Open Access Research article

Modularity as a source of new morphological variation in the mandible of hybrid mice

Sabrina Renaud1*, Paul Alibert2 and Jean-Christophe Auffray3

Author Affiliations

1 Laboratoire de Biométrie et Biologie Evolutive, UMR 5558, CNRS, Université Lyon 1, 69622, Villeurbanne, France

2 Biogéosciences, CNRS, Université de Bourgogne, 21000, Dijon, France

3 Institut des Sciences de l’Evolution, CNRS, Université Montpellier 2, 34095, Montpellier, France

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BMC Evolutionary Biology 2012, 12:141  doi:10.1186/1471-2148-12-141

Published: 8 August 2012

Abstract

Background

Hybridization is often seen as a process dampening phenotypic differences accumulated between diverging evolutionary units. For a complex trait comprising several relatively independent modules, hybridization may however simply generate new phenotypes, by combining into a new mosaic modules inherited from each parental groups and parts intermediate with respect to the parental groups. We tested this hypothesis by studying mandible size and shape in a set of first and second generation hybrids resulting from inbred wild-derived laboratory strains documenting two subspecies of house mice, Musmusculus domesticus and Musmusculus musculus. Phenotypic variation of the mandible was divided into nested partitions of developmental, evolutionary and functional modules.

Results

The size and shape of the modules were differently influenced by hybridization. Some modules seemed to be the result of typical additive effects with hybrids intermediate between parents, some displayed a pattern expected in the case of monogenic dominance, whereas in other modules, hybrids were transgressive. The result is interpreted as the production of novel mandible morphologies. Beyond this modularity, modules in functional interaction tended to display significant covariations.

Conclusions

Modularity emerges as a source of novel morphological variation by its simple potential to combine different parts of the parental phenotypes into a novel offspring mosaic of modules. This effect is partly counterbalanced by bone remodeling insuring an integration of the mosaic mandible into a functional ensemble, adding a non-genetic component to the production of transgressive phenotypes in hybrids.

Keywords:
Mus musculus; House mouse; Mandible shape; Hybridization; Geometric morphometrics; Transgressive phenotypes