Figure 3.

Bayesian phylogenetic tree of HIN domains from a range of placental and marsupial mammals rooted with marsupial sequences. Posterior probabilities ≥0.7 in this analysis are shown above the nodes. Clades that were supported by PhyML analysis (with likelihood-ratio test values >0.85, except as indicated) are shown by dots on the nodes. For a limited number of important nodes the PhyML likelihood-ratio test values are shown as a number below the node. Dotted lines separate observable HIN clades: placental HIN-A, -B, and -C, and marsupial HIN-D. Sequences used are specified in Table 1 and Additional File 2: Table S2, and the alignment is shown in Additional File 3: Figure S3.