Resolution:
## Figure 3.
Hierarchical clustering of cellular compartments based on selective constraint. Genes are split into nine groups based on their subcellular location (see main text).
The median box plots show the distribution of ω values for each compartment - all
data, including outliers, are used in the analysis. Using the mean ω values, we created
a phenogram using the UPGMA algorithm (branch lengths are arbitrary). Each branch
is colored gold if a Mann-Whitney U-test found that the distributions were significantly
different at P ≤ 0.01, and blue otherwise. For example, the cytoplasm and mitochondria distributions
are significantly different (P = 0.01), but the lysozyme and transport groups show no significant difference (P = 0.087). However, when the group formed by the cytoplasm and mitochondria is compared
to that formed by the lysozyme and transporters, there is a statistically significant
difference (P < 0.001). The 4 Venn diagrams show the proportional degree of overlap in genes among
groups (sizes are not comparable across nodes in the tree). In none of these cases
is any one set of reactions a superset of the other set of reactions.
Hudson and Conant |