POP2 is present in hominid and Old World primates. A. Protein sequences of the PYDs most closely related to that of POP2 from the genome sequences of human, the non-human hominid primates Pan troglodytes (chimpanzee) and Pongo abelii (orangutan; 6 × coverage), the Old World primate Macaca mulatta (Rhesus macaque), and the New World primate Callithrix jacchus (marmoset; 6 × coverage). Percent identity/similarity and expect values are shown at right to the aligned sequences. B. Genomic maps of the POP2 loci for genomes with chromosomal map data from the indicated species. Gray indicates presumed gene locations and approximate distances in the marmoset genome. Note: Marmoset contig 6464-5 which corresponds by position with POP2 lacks a start codon and intact open reading frame. Vestiges of the nucleotide binding and leucine-rich repeats analogous to NLRP2/7 are contiguous in the sequence immediate downstream of the PYD-like sequence.
Atianand et al. BMC Evolutionary Biology 2011 11:56 doi:10.1186/1471-2148-11-56