Table 1

Mutations and perturbations in the initial condition s0 produce the same phenotypes more often than expected by chance

N

c

d

Mean C ± S.E.

p-value

Sample sizea


8

0.4

0.125

0.528 ± 0.006

< 2.2 × 10-16

5485


0.25

0.496 ± 0.006

< 2.2 × 10-16

5905


0.5

0.557 ± 0.005

< 2.2 × 10-16

7269


0.3

0.125

0.442 ± 0.006

< 2.2 × 10-16

5885


0.25

0.398 ± 0.006

< 2.2 × 10-16

6050


0.5

0.349 ± 0.005

< 2.2 × 10-16

7144


20

0.3

0.1

0.712 ± 0.006

< 2.2 × 10-16

5247


0.25

0.8 ± 0.005

< 2.2 × 10-16

6432


0.5

0.885 ± 0.003

< 2.2 × 10-16

8055


0.2

0.1

0.63 ± 0.006

< 2.2 × 10-16

5318


0.25

0.645 ± 0.006

< 2.2 × 10-16

5699


0.5

0.711 ± 0.005

< 2.2 × 10-16

7102


0.1

0.1

0.47 ± 0.006

< 2.2 × 10-16

6036


0.25

0.408 ± 0.006

< 2.2 × 10-16

6058


0.5

0.364 ± 0.005

< 2.2 × 10-16

6776


C >Crand, according to a Wilcoxon signed-rank test. In this and all other tables, N refers to the number of genes in a circuit, c refers to the circuit's interaction density, and d refers to the fraction of gene activity differences between the unperturbed initial condition s0 and the native phenotype <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M3','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M3">View MathML</a>.

a Even though we sampled 104 genotypes for each genotype network, we discarded genotypes in which either Pμ or <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M4','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M4">View MathML</a> was empty.

Espinosa-Soto et al. BMC Evolutionary Biology 2011 11:5   doi:10.1186/1471-2148-11-5

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