Figure 4.

Genetic distance to a genotype network is negatively correlated with a phenotype's penetrance. (a) The leftmost circle represents a genotype G, where an alternative phenotype <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M6">View MathML</a> has a given penetrance (red sector). We quantified the penetrance of <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M6">View MathML</a> in G as the fraction of single-gene perturbations of the initial condition s0 that produce <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M6">View MathML</a>. We determined genetic distance as the smallest number of mutations required to reach <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M6">View MathML</a>'s genotype network (rightmost circle). (b) The horizontal axis shows the penetrance of a phenotype <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M6">View MathML</a>. The vertical axis shows the distance to <a onClick="popup('http://www.biomedcentral.com/1471-2148/11/5/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2148/11/5/mathml/M6">View MathML</a>'s genotype network. A circle's area is proportional to the number of data points in each penetrance and mutational distance category. The panel is based on 104 circuit genotypes with N = 16 genes, c ≈ 0.35, and d = 0.25. Penetrance and genetic distance to the new genotype network are negatively associated (Spearman's ρ = -0.293; p < 2.2 × 10-16). The inset shows that the fraction of genotypes that are neighbors of the new genotype network increases with penetrance.

Espinosa-Soto et al. BMC Evolutionary Biology 2011 11:5   doi:10.1186/1471-2148-11-5
Download authors' original image