The more similar two circuit genotypes are, the higher the overlap between their sets of alternative phenotypes. The number k represents the distance (in the number of differing regulatory interactions) between two circuits. Ck measures the similarity between the sets of alternative phenotypes produced by the two circuits. The plot shows mean values and the length of error bars represents one standard error. Spearman's ρ = -0.248; p < 2.2 × 10-16. The inset shows that the fraction of genotype pairs that share a given alternative phenotype decreases with k. Data are based on 104 randomly sampled focal circuits with N = 20, c ≈ 0.2, and d= 0.1.
Espinosa-Soto et al. BMC Evolutionary Biology 2011 11:5 doi:10.1186/1471-2148-11-5