Phylogenetic tree of phosphoinositide 3-kinases (PI3K) and Type III phosphoinositide 4-kinases (PI4K). PI3K proteins are labeled according to HUGO human gene name with classes identified by commonly accepted nomenclature . Main organism taxonomic groups are color coded. For simplicity, Protosomatia (insects/arthropods), Pseudocoelomata (nematode worms) are considered collectively as Invertebrates. The tree was reconstructed by neighbor-joining (NJ) method using protein distance matrices of core conserved amino acids (see Methods). Asterisks ("*") indicate those nodes supported 70% or greater in 1000 bootstrap replicate NJ trees and 0.95 Bayesian posterior probability. Scale bar represents 0.1 expected amino acid residue substitutions per site.
Brown and Auger BMC Evolutionary Biology 2011 11:4 doi:10.1186/1471-2148-11-4