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Open Access Research article

Signatures of positive selection in Toll-like receptor (TLR) genes in mammals

Helena Areal12, Joana Abrantes13 and Pedro J Esteves14*

Author Affiliations

1 CIBIO-UP, Centro de Investigacao em Biodiversidade e Recursos Geneticos - Universidade do Porto, Campus Agrario de Vairao, Rua Padre Armando Quintas, nr.7, 4485-661 Vairao, Portugal

2 Departamento de Zoologia e Antropologia da Faculdade de Ciencias, Universidade do Porto, Porto, Portugal

3 INSERM, U892, Universite de Nantes, 44007 Nantes, France

4 CITS, Centro de Investigacao em Tecnologias de Saude, CESPU, Gandra, Portugal

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BMC Evolutionary Biology 2011, 11:368  doi:10.1186/1471-2148-11-368

Published: 20 December 2011

Additional files

Additional file 1:

Table S1. Identification of the sequences used for the TLR1 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR1 alignment.

Format: DOC Size: 104KB Download file

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Additional file 2:

Table S2. Identification of the sequences used for the TLR2 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR2 alignment.

Format: DOC Size: 124KB Download file

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Additional file 3:

Table S3. Identification of the sequences used for the TLR3 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR3 alignment.

Format: DOC Size: 113KB Download file

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Additional file 4:

Table S4. Identification of the sequences used for the TLR4 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR4 alignment.

Format: DOC Size: 110KB Download file

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Additional file 5:

Table S5. Identification of the sequences used for the TLR5 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR5 alignment.

Format: DOC Size: 109KB Download file

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Additional file 6:

Table S6. Identification of the sequences used for the TLR6 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR6 alignment.

Format: DOC Size: 114KB Download file

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Additional file 7:

Table S7. Identification of the sequences used for the TLR7 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR7 alignment.

Format: DOC Size: 118KB Download file

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Additional file 8:

Table S8. Identification of the sequences used for the TLR8 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR8 alignment.

Format: DOC Size: 106KB Download file

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Additional file 9:

Table S9. Identification of the sequences used for the TLR9 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR9 alignment.

Format: DOC Size: 116KB Download file

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Additional file 10:

Table S10. Identification of the sequences used for the TLR10 alignment. Microsoft Word document containing the list of accession numbers of the sequences used for the TLR10 alignment.

Format: DOC Size: 90KB Download file

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Additional file 11:

Table S11. Amino acid alterations found in TLR1 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR1 gene.

Format: DOC Size: 116KB Download file

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Additional file 12:

Table S12. Amino acid alterations found in TLR2 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR2 gene.

Format: DOC Size: 256KB Download file

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Additional file 13:

Table S13. Amino acid alterations found in TLR3 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR3 gene.

Format: DOC Size: 291KB Download file

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Additional file 14:

Table S14. Amino acid alterations found in TLR4 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR4 gene.

Format: DOC Size: 203KB Download file

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Additional file 15:

Table S15. Amino acid alterations found in TLR5 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR5 gene.

Format: DOC Size: 209KB Download file

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Additional file 16:

Table S16. Amino acid alterations found in TLR6 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR6 gene.

Format: DOC Size: 151KB Download file

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Additional file 17:

Table S17. Amino acid alterations found in TLR7 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR7 gene.

Format: DOC Size: 262KB Download file

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Additional file 18:

Table S18. Amino acid alterations found in TLR8 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR8 gene.

Format: DOC Size: 213KB Download file

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Additional file 19:

Table S19. Amino acid alterations found in TLR9 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR9 gene.

Format: DOC Size: 181KB Download file

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Additional file 20:

Table S20. Amino acid alterations found in TLR10 for each species at each positively selected site. Microsoft Word document containing the amino acid alterations at each site under selection in TLR10 gene.

Format: DOC Size: 183KB Download file

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Additional file 21:

Table S21. Domain characterization of TLR1. Microsoft Word document containing the list of domains of Human TLR1 gene, their delimitation and sequence.

Format: DOC Size: 225KB Download file

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Open Data

Additional file 22:

Table S22. Domain characterization of TLR2. Microsoft Word document containing the list of domains of Human TLR2 gene, their delimitation and sequence.

Format: DOC Size: 227KB Download file

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Open Data

Additional file 23:

Table S23. Domain characterization of TLR3. Microsoft Word document containing the list of domains of Human TLR3 gene, their delimitation and sequence.

Format: DOC Size: 250KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 24:

Table S24. Domain characterization of TLR4. Microsoft Word document containing the list of domains of Human TLR4 gene, their delimitation and sequence.

Format: DOC Size: 244KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 25:

Table S25. Domain characterization of TLR5. Microsoft Word document containing the list of domains of Human TLR5 gene, their delimitation and sequence.

Format: DOC Size: 239KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 26:

Table S26. Domain characterization of TLR6. Microsoft Word document containing the list of domains of Human TLR6 gene, their delimitation and sequence.

Format: DOC Size: 224KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 27:

Table S27. Domain characterization of TLR7. Microsoft Word document containing the list of domains of Human TLR7 gene, their delimitation and sequence.

Format: DOC Size: 261KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 28:

Table S28. Domain characterization of TLR8. Microsoft Word document containing the list of domains of Human TLR8 gene, their delimitation and sequence.

Format: DOC Size: 272KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 29:

Table S29. Domain characterization of TLR9. Microsoft Word document containing the list of domains of Human TLR9 gene, their delimitation and sequence.

Format: DOC Size: 263KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 30:

Table S30. Domain characterization of TLR10. Microsoft Word document containing the list of domains of Human TLR10 gene, their delimitation and sequence.

Format: DOC Size: 228KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 31:

Table S31. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR1. Microsoft Word document containing the list of PSC in TLR1 and their localization in domains of Human TLR1 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 104KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 32:

Table S32. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR2. Microsoft Word document containing the list of PSC in TLR2 and their localization in domains of Human TLR2 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 247KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 33:

Table S33. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR3. Microsoft Word document containing the list of PSC in TLR3 and their localization in domains of Human TLR3 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 261KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 34:

Table S34. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR4. Microsoft Word document containing the list of PSC in TLR4 and their localization in domains of Human TLR4 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 343KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 35:

Table S35. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR5. Microsoft Word document containing the list of PSC in TLR5 and their localization in domains of Human TLR5 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 248KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 36:

Table S36. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR6. Microsoft Word document containing the list of PSC in TLR6 and their localization in domains of Human TLR6 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 138KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 37:

Table S37. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR7. Microsoft Word document containing the list of PSC in TLR7 and their localization in domains of Human TLR7 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 228KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 38:

Table S38. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR8. Microsoft Word document containing the list of PSC in TLR8 and their localization in domains of Human TLR8 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 376KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 39:

Table S39. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR9. Microsoft Word document containing the list of PSC in TLR9 and their localization in domains of Human TLR9 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 157KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data

Additional file 40:

Table S40. Characterization of the amino acids possibilities for each residue identified under positive selection in TLR10. Microsoft Word document containing the list of PSC in TLR10 and their localization in domains of Human TLR10 gene. For each site, we list the amino acid possibilities and the characterization of their polarity and charge.

Format: DOC Size: 205KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data