Functional overlap of paralogous pairs. (A) DiceM coefficient for all the paralogous pairs (red bars). Grey bars refer to 106 randomly selected pairs. (B) Scheme of the pathway section including two isozymes YMR271C (URA10) e YML106W (URA5) sharing 75% amino acid similarity and responsible for the same reaction, the conversion of orotate into orotidine-5'-phosphate.
Grassi and Tramontano BMC Evolutionary Biology 2011 11:301 doi:10.1186/1471-2148-11-301