Test of region-specific gene conversion. Gene duplication occurred before the divergence of two species (α and β) and each species has two copies of genes (1 and 2). A) When gene conversion occurred after the divergence of two species, the tree topology would become the type-C tree (right); otherwise the tree would become the type-N tree (left). B) The log-likelihood values of the type-N (red lines) and type-C trees (black lines) in the human-mouse quartet genes. Substrate recognition sites (SRS) and heme-binding regions (HBR) are shown as the blue squares. The vertical dashed lines represent boundaries between exons. C) The log-likelihood values in the human-marmoset quartet genes.
Uno and Osada BMC Evolutionary Biology 2011 11:283 doi:10.1186/1471-2148-11-283