The 3D distance distribution of the coevolving residue pairs compared to all residue pairs in Rubisco. This is the minimum distance of the pair-wise residues between the active state and un-active state of Rubisco (based on the Spinacia oleracea structure 8RUC). Solid line is the distribution of pair-wise distances for coevolving residues. Dash line is the distribution of pair-wise distances for all protein residues.
Wang et al. BMC Evolutionary Biology 2011 11:266 doi:10.1186/1471-2148-11-266