Conservation-hydrophilicity plots and single-nucleotide changes in the hominid malaria clade in calcium-ATPase genes. (a) PfSERCA (PFA0310c) showing amino acid variants between P. falciparum and P. reichenowi and field amino acid variants (see Table 3); symbol size indicates maximum allele frequency on a countrywide basis. (b) PfATPase4 (PFL0590c), showing amino acid variants between P. falciparum and P. reichenowi as well as the mutations associated with spiroindolone selection (see text). Conservation and hydrophilicity are derived as for Figure 3.
Gardner et al. BMC Evolutionary Biology 2011 11:257 doi:10.1186/1471-2148-11-257