Identification of invertebrate LNX orthologs. Lineages in which LNX orthologs can be identified are represented on a simplified phylogenetic tree of metazoans. Domain structures of predicted proteins from a representative species in each lineage are indicated. Proteins are classified as being orthologs of vertebrate LNX1 and LNX2 (LNX1/2) or vertebrate LNX3 and LNX4 (LNX3/4). LNX3/4 orthologs were identified based on the presence of both a RING and PDZ domain, or the presence of the LNX3H domain. The C. intestinalis and S. pupuratus LNX3/4 sequences are incomplete.
Flynn et al. BMC Evolutionary Biology 2011 11:235 doi:10.1186/1471-2148-11-235