Figure 3.

GPRC5-like sequences in invertebrates. (A) Phylogenetic tree of GPRC5-like sequences from invertebrates together with GPRC5B and GPRC5C from mammals (Mus musculus (Mm), Homo sapiens (Hs)) and calcium sensing receptors (CaSR), pheromone receptors (V2R2), metabotrope glutamate receptors (mGluR) and GABA receptors (GABA-A and GABA-B). Branch labels indicate posterior probabilities. Branch lengths represent phylogenetic distances. The burnin value for the Bayesian analysis was 500. (B) Domain structure of GPRC5 receptors and GPRC5-like sequences in invertebrates. Sequences are aligned at their 7TM domain areas (dark grey). The number of amino acids in each sequence is indicated on the right. GPRC5 sequences are highlighted in red in A and B.