Figure 2.

Protein domain arrangements of different biotin protein ligases and biotin-dependent carboxylases with respect to their functions and phylogenetic origins. (A) Biotin protein ligases (BPL) and (B) biotin-dependent carboxylases. Homologous protein domains in different enzymes are shown in the same colors and filling. ACC: acetyl-CoA carboxylase; PCC: propionyl-CoA carboxylase; MCC: methylcrotonyl-CoA carboxylase; GCC: geranyl-CoA carboxylase; PYC: pyruvate carboxylase; UCA: urea carboxylase; BC: biotin carboxylase; BCCP: biotin carboxyl carrier protein; CCT: CoA-substrate related carboxyl transferase; PCT: PYC-related carboxyl tranferase; UCT: UCA-related carboxyl tranferase; BT: BC-CT interaction domain; PT: PYC tetramerization.