Genomic architecture of the Ush1g-Otop2-Otop3 locus in vertebrates. (a) Mouse genomic region encompassing the Ush1g, Otop2, and Otop3 genes. The relative positions and transcriptional orientation of the indicated genes are drawn to scale, with the genomic structures of Ush1g, Otop2, and Otop3 provided in greater detail. Note the red, orange, and purple lines that indicate how three known splice forms of mouse Otop2 are derived from the use of four alternate non-coding exons (named 1a to 1d) and two internal splice donor sites in exons 1d and 2. The identical organization of genes within the depicted genomic region is also in found human, chimpanzee, orangutan, macaque, marmoset, galago, rat, guinea pig, horse, cow, cat, dog, armadillo, opossum, and chicken. (b) X. tropicalis genomic region encompassing the Ush1g, Otop2, and Otop3 genes. Note the presence of three paralogous genes for both Otop2 and Otop3 (for details about the phylogenetic relationships of the Otop genes in amphibian and selected vertebrates, see Figure 2). (c) Stickleback genomic regions containing the Ush1g, Otop2, and Otop3 genes showing a complex duplication and rearrangement pattern (see text for details).
Hurle et al. BMC Evolutionary Biology 2011 11:23 doi:10.1186/1471-2148-11-23