Examples of conversion events in the human β-globin cluster. Blue underlays in the plots represent conversion regions. Black lines show sequence similarities between a human region and its human paralog, and brown lines between the human region and its ortholog in the outgroup species. In each plot, the y-axis corresponds to the percent identity of the two sequences (50%-100%). Note how the black paralogs lie above the brown orthologs in the converted region, but fall below them in the flanking regions. (A) depicts a conversion event in the first exon and intron of the human δ gene, copied from the human β gene (standard coordinates for this human chromosome have the genes of the β-globin cluster transcribed from right to left). This event was detected using the marmoset ortholog of human δ. (B) shows a converted region covering the human γ2 gene. Its paralog is γ1 in human, and the gibbon ortholog of human γ2 was used for this conversion observation.
Song et al. BMC Evolutionary Biology 2011 11:226 doi:10.1186/1471-2148-11-226