Additional file 4.

Proteins from Archea genomes containing NHL domains. Description: Putative proteins with NHL domains in eukaryotic, bacterial, and archea genomes were identified using the SUPERFAMILY database. Hundreds of proteins in eukaryotic and bacterial genomes were identified and were not further analyzed. Three positive archea hits were subsequently analyzed using PFAM, InterProScan, and SMART for confirmation. In addition, predicted secondary structure was analyzed using JPRED and PSIPRED. Predicted consensus secondary structure is displayed over the sequences with arrows representing β-sheets. The predicted NHL domains are highlighted with green boxes. Protein identification numbers are: Halalkallcoccus-YP_685176.1, Halomicrobium-YP_003178756.1, and archaeon RC-I-YP_003736383.1.

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Romá-Mateo et al. BMC Evolutionary Biology 2011 11:225   doi:10.1186/1471-2148-11-225