Schematic representation of mutation distribution in gapless alignment of cyclins. Cyclins: A, animal A; B, animal B; C, fungal B; D, animal B3; E, animal D; F, animal E. Atypical replacements are indicated above each rectangle in Figures A through E. The upper rectangle in Figures A through E represents the position of amino acids in protein globule sample by color transitions from black, inner amino acids, to white, those on the surface. The lower rectangle in Figures A through E represents the secondary structure in protein sample: black, helical structure, white, turns. Fringes of secondary structure are colored depending on whether the number of all replacements is significantly greater (red) than expected, or as expected (white).
Gunbin et al. BMC Evolutionary Biology 2011 11:224 doi:10.1186/1471-2148-11-224