Table 2

Number of genes in each functional class with evidences of adaptive selection

Functional Class

Africans

Europeans


N

Positive Selection

Balancing Selection

Positive Selection

Balancing Selection


Receptors

19

TLR2

LY96

LY64a, TLR9, TLR10a

CD14, LY96, TLR6

Adaptors

10

-

-

IRAK4a

-

Modulators

6

SOCS2a, TOLLIP

-

-

-

Acute Phase

20

-

LTA, IL18RAP, IL1F5, IL1F7

IL18BPa

IL1F5, IL1A, IL1F10, IL18RAP, IL1F7

Cellular Immunity

10

-

-

-

-

Antiinf. Cytokines

10

-

-

TGFB2

-

Neutrophil

9

IL17Ba

-

-

-

Chemokines

14

IL8a

-

CCR4

-

Extracellular

6

-

-

ADAM33

-

Complement

8

-

CFH, C5, C3

-

C3

Effector

15

MPO, NGFR

NTRK1

MPO

ITGA8

Non classified

5

CTNNB1

-

TNFRSF18

-


N, number of genes in each functional category.

a Genes with evidences of positive selection showing an excess of derived alleles at high frequencies (Fay and Wu's H test).

Casals et al. BMC Evolutionary Biology 2011 11:202   doi:10.1186/1471-2148-11-202

Open Data