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Open Access Highly Accessed Research article

The dynamics of vertebrate homeobox gene evolution: gain and loss of genes in mouse and human lineages

Ying-fu Zhong and Peter WH Holland*

Author Affiliations

Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK

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BMC Evolutionary Biology 2011, 11:169  doi:10.1186/1471-2148-11-169

Published: 16 June 2011

Additional files

Additional file 1:

All human homeobox genes and pseudogenes: classification, chromosomal location, homeodomain sequence, database identification numbers and synonyms.

Format: XLSX Size: 54KB Download file

Open Data

Additional file 2:

Comparison of human and mouse homeobox gene repertoires classified by gene family.

Format: XLSX Size: 15KB Download file

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Additional file 3:

All mouse homeobox genes and pseudogenes: classification, chromosomal location, homeodomain sequence, database identification numbers and synonyms.

Format: XLSX Size: 49KB Download file

Open Data

Additional file 4:

Unannotated mouse homeobox loci: chromosomal location, accession number, homeodomain sequence and similarity.

Format: XLSX Size: 10KB Download file

Open Data

Additional file 5:

LEUTX orthologues in human, chimpanzee and macaque. (A) Alignment of homeodomains showing high sequence conservation. (B) Syntenic chromosomal regions around LEUTX genes.

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Additional file 6:

Refined structure of TPRX1 gene at human chromosome 19q13.33. (A) The TPRX1 locus is incorrectly annotated in the NCBI and EBI assemblies with a truncation at the 5' end. This predicts an incomplete homeodomain, even though the entire homeobox region is present in the genome sequence. (B) Revised gene model for TPRX1 based on cDNA data in GenBank, accessions AK097640, BC137501, BC144673, BC141863, DQ340180. Additional 5' exons are present, predicting a complete homeodomain sequence.

Format: PPT Size: 225KB Download file

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Open Data