Alternative splicing in GAPD-2 of Anolis carolinensis. Alternative splicing seems to govern the proline-rich domain presence in GAPD-2 of a lizard Anolis carolinensis. If the second exon is spliced, the protein product will lack the proline-rich domain, otherwise it will possess this domain. A) Map of GAPD-2 gene constructed based on both Ensembl and EST data. Exons are in yellow, introns and not-transcribed regions are in blue. The positions of the two possible translation initiation sites are marked, as well the position of the translation termination site. B) Alignment of the 5'-termini of full-length and shortened (lacking the second exon) mRNAs. The sequences of possible protein products are also represented.
Kuravsky et al. BMC Evolutionary Biology 2011 11:160 doi:10.1186/1471-2148-11-160