Table 1

Proteins considered in this analysis

Protein (Abbreviation)

PID (Hs)1

Path-way2

Class3

H-M4


Glucokinase (GK)

P35557

G

U

98.3

6-phosphofructokinase (F6P)

P17858

G

U

97.0

fructose-bisphosphate aldolase (A) (FBa)

P04075

G

U

98.9

fructose-bisphosphate aldolase (B) (FBb)

P05062

G

U

99.7

fructose-bisphosphate aldolase (C) (FBc)

P09972

G

U

98.6

glyceraldehyde 3-phosphate dehydrogenase (GAPD)

P04406

G

U

97.0

bisphosphoglycerate phosphatase (1) (PGP1)

P18669

G

U

99.6

bisphosphoglycerate phosphatase (2) (PGP2)

P15259

G

U

95.2

Pyruvate kinase (PK)

P30613

G

U

95.5

Lactate dehydrogenase A (LDHa)

P00338

G

U

97.6

Lactate dehydrogenase B (LDHb)

P07195

G

U

99.1

Pyruvate Dehydrogenase Complex A (PDCa)

P08559

T

U

99.5

Pyruvate Dehydrogenase Complex B (PDCb)

P11177

T

U

97.5

Pyruvate Dehydrogenase Complex C (PDCc)

P29803

T

U

87.2

Citrate Synthase (CS)

O75390

T, P

U

97.4

Aconitase (ACO)

Q99798

T, P

U

98.8

Isocitrate Dehydrogenase (NAD+) (A) (IDHa)

P50213

T, P

U

98.6

Isocitrate Dehydrogenase (NAD+) (G) (IDHg)

P51553

T, P

U

97.2

Oxoglutarate Dehydrogenase Complex (OGDC)

Q02218

T

U

94.1

Succinyl-CoA synthetase A (SCSa)

P53597

T

U

97.0

Succinyl-CoA synthetase B (SCSb)

Q96I99

T

U

96.1

Succinate Dehydrogenase A (SDHa)

P31040

T

U

94.0

Succinate Dehydrogenase B (SDHb)

P21912

T

U

97.0

Fumarase (FM)

P07954

T, N

U

95.3

Malate Dehydrogenase (mitochondrion & cytosol) (MDH)

P40926

T, N

U

97.6

Alanine Transaminase (AlaTA)

P24298

N

U

92.5

Aspartate Transaminase (AspTA)

P00505

N

U

98.4

Nucleoside Diphosphate Kinase (NDK)

O00746

T

U

87.8

NADH: Ubiquinone oxidoreductase 1 (MT-ND1)

O15239

R

E

92.9

NADH: Ubiquinone oxidoreductase 2 (MT-ND2)

O43678

R

E

93.9

NADH: Ubiquinone oxidoreductase 3 (MT-ND3)

O95167

R

E

88.1

NADH: Ubiquinone oxidoreductase 4 (MT-ND4)

O00483

R

E

92.7

NADH: Ubiquinone oxidoreductase 5 (MT-ND5)

Q16718

R

U

91.3

NADH: Ubiquinone oxidoreductase 6 (MT-ND6)

P56556

R

U

90.8

NADH: Ubiquinone oxidoreductase 7 (MT-ND7)

O95182

R

E

95.5

NADH: Ubiquinone oxidoreductase 8 (MT-ND8)

P51970

R

U

94.7

NADH: Ubiquinone oxidoreductase 9 (MT-ND9)

Q16795

R

U

87.3

Ubiquinol: Cytochrome c Oxidoreductase H (UQCRH)

P08574

R

U

92.3

Ubiquinol: Cytochrome c Oxidoreductase I (UQCRI)

P47985

R

U

94.5

Ubiquinol: Cytochrome c Oxidoreductase Q (UQCRQ)

O14949

R

E

85.2

Ubiquinol: Cytochrome c Oxidoreductase R1 (UQCRR1)

O14957

R

M

92.7

Ubiquinol: Cytochrome c Oxidoreductase C2 (UQCRC2)

P22695

R

U

93.2

Cytochrome c Oxidase 6B1 (Cox6B1)

P14854

R

E

96.5

Cytochrome c Oxidase 2* (Cox2)

P00403

R

U

86.8

Cytochrome c Oxidase 8a (Cox8a)

P10176

R

V

85.5

Cytochrome c Oxidase 5A (Cox5a)

P20674

R

U

88.0

Cytochrome c Oxidase 4A (Cox4a)

P13073

R

E

89.9

Cytochrome c Oxidase 6C (Cox6c)

P09669

R

M

86.7

Cytochrome c Oxidase 7B (Cox7b)

P24311

R

V

88.8

Cytochrome c Oxidase 1* (Cox1)

P00395

R

U

95.5

Cytochrome c Oxidase 7R (Cox7r)

O14548

R

E

93.0

Cytochrome c Oxidase 7C (Cox7c)

P15954

R

E

88.9

Oxoglutarate Carrier (OGC)

Q02978

N, P

E

97.8

Citrate Carrier (CIC)

P53007

M

E

96.5

Nicotinamide nucleotide transhydrogenase (NNT)

Q13423

S

U

96.2

Glutathione reductase (GSSGR)

P00390

S

U

89.3

Glutathione peroxidase (GSSGP)

P07203

S

U

90.6

Glycerol-3-phosphate dehydrogenase (FAD dependent) (GUT2P)

P43304

N

U

97.0

Glycerol-3-phosphate dehydrogenase (NAD+) (G3PD)

P21695

N

U

96.8

Malate Dehydrogenase (oxaloacetate-decarboxylating) (NADP+) X (MEx)

P48163

P

U

94.9

Malate Dehydrogenase (oxaloacetate-decarboxylating)(NADP+) N (Men)

Q16798

P

U

96.4

ATP/ADP Carrier 2 (AAC)

P05141

M

U

99.3

cytosolic Isocitrate Dehydrogenase (NADP+) P (IDHcp)

P48735

P

U

82.0

cytosolic Isocitrate Dehydrogenase (NADP+) C (IDHcc)

O75874

P

U

97.8

Pyruvate Carboxylase (PC)

P11498

T, P

U

98.6

ETF:Q oxidoreductase (ETF-QO)

Q16134

N

U

95.8

Manganese-dependent superoxide dismutase 2 C (SOD2c)

P00441

S

U

88.9

Manganese-dependent superoxide dismutase 2 M (SOD2 m)

P04179

S

U

91.9

Manganese-dependent superoxide dismutase 2 E (SOD2e)

P08294

S

U

75.2


1 Uniprot Accession ID for the human protein

2 Pathway designation: G = glycolysis, T = TCA cycle, R = respiratory chain, N = NADH shuttle, P = pyruvate cycle, M = metabolite transport, S = glutathione pathway

3 Phylogenetic class

4 Human-mouse sequence similarity (%)

Ainali et al. BMC Evolutionary Biology 2011 11:142   doi:10.1186/1471-2148-11-142

Open Data