Corticosteroid receptor ligand specificity. Graphs showing relative fold-activation over ethanol for midshipman and mouse LBD constructs to 10-7 M of each steroid treatment. MRs (A, B) showed expected sensitivity to both cortisol and aldosterone. GRs (C-E) were all sensitive to cortisol, but showed variable sensitivity to aldosterone. None of the receptors were activated by either cortisone or 11-ketotestosterone (11-KT).
Arterbery et al. BMC Evolutionary Biology 2011 11:14 doi:10.1186/1471-2148-11-14