Phylogram of the evolutionary relationship of corticosteroid receptors based on DNA sequence identity. In addition to the receptors examined in this study (mouse, Mus musculus; midshipman fish, Porichthys notatus; daffodil cichlid, Neolamprologous pulcher), we included GRs and MRs from another cichlid (Burton's cichlid, Astatotilapia burtoni); a cartilaginous fish, the little skate (Leucoraja erinacea); and rainbow trout (Oncorhynchus mykiss) which have all been used in similar transactivational studies [2,12,13,25]. The Burton's cichlid GRs are named according to a revised nomenclature . Also included are the general corticosteroid receptor of a hagfish (Myxine glutinosa) and lamprey (Petromyzon marinus) that are evolutionarily basal to the radiation of GRs and MRs. The superscripts 'A' and 'C' indicate sensitivity to aldosterone and cortisol at ≤ 10-7 M based on our results and previous studies. *Aldosterone sensitivities of Burton's cichlid GR1 and rainbow trout GR2 are somewhat unclear [2,12,13].
Arterbery et al. BMC Evolutionary Biology 2011 11:14 doi:10.1186/1471-2148-11-14