Table 3

Constraints of functions on the co-origins of motif constituents

Functional

Category a

The total number

Age homogeneity rate (%) c

Empirical P -value b

Age homogeneity ratio c


Real network

Average of 1000 random networks


3-motif


Metabolism

3201

14.53

10.15

0.044

1.43

Energy

270

10.00

10.25

0.436

0.98

Cell cycle

5594

21.15

10.11

<10-3

2.09

Transcription

6784

33.89

10.04

<10-3

3.37

Protein synthesis

305

34.43

10.32

0.001

3.34

protein fate

7173

37.82

10.19

<10-3

3.71

Binding protein

4755

26.71

10.14

<10-3

2.63

Regulation of metabolism

96

25.00

10.23

0.021

2.44

Cellular transport

6811

29.14

10.11

<10-3

2.88

Signal transduction

399

14.29

10.32

0.137

1.38

Cell defense

571

18.91

10.15

0.008

1.86

environment interaction

759

16.34

10.16

0.033

1.61

Cell fate

1505

19.73

10.12

0.003

1.95

Cellular components

3521

21.02

10.10

<10-3

2.08

Cell differentiation

2378

18.84

10.10

0.002

1.87


4-motif


Metabolism

22981

5.07

3.75

0.178

1.35

Energy

949

1.79

3.65

0.641

0.49

Cell cycle

57466

8.57

3.61

0.019

2.37

Transcription

53928

24.05

3.66

<10-3

6.58

Protein synthesis

765

18.95

3.64

0.002

5.21

protein fate

61470

29.36

3.66

<10-3

8.02

Binding protein

29905

17.69

3.64

<10-3

4.86

Regulation of metabolism

142

14.79

3.85

0.025

3.84

Cellular transport

61230

17.93

3.64

<10-3

4.93

Signal transduction

1397

5.01

3.69

0.238

1.36

Cell defense

1889

8.31

3.72

0.038

2.23

environment interaction

2486

6.60

3.80

0.091

1.74

Cell fate

9484

8.31

3.65

0.016

2.28

Cellular components

24647

9.39

3.59

0.001

2.62

Cell differentiation

17140

8.05

3.61

0.007

2.23


a Protein functional categories are based on FunCat functional classification system [49]. Here we list their abbreviations and please refer to Table S12 in additional file 1 for the details. b We list upper-tailed empirical P -values (enrichment), which are lower than 0.05 are highlighted in bold. c Please refer to the footnotes of Table 2 for the definitions of age homogeneity rate and age homogeneity ratio.

Liu et al. BMC Evolutionary Biology 2011 11:133   doi:10.1186/1471-2148-11-133

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