Additional file 3.
The effect of antibiotic dosage intensity and the interval between treatments on the cell types persisting at equilibrium for the extended model. "F" denotes wild-type cells, "P" denotes cells infected with a plasmid carrying resistance and "C" denotes cells with resistance on the chromosome and "B" denotes cells carrying plasmids that do not code for resistance genes. Plasmid segregation s = 0.01 (in figure A) and s = 0.0001 (in figure B). Cell types that are present in the population at a density greater than exceeding 0.001 are shown. The plots were calculated by running the simulation for a number of parameter values for 5,000 time-steps. Lines were then smoothed by interpolation. Parameters used are r = 1, β = 0.1, a = 1, cc = 0.02, cp = 0.02, x = 0.05, m = 0.1 and l = 0.5.
Format: PDF Size: 99KB Download file
This file can be viewed with: Adobe Acrobat Reader
Svara and Rankin BMC Evolutionary Biology 2011 11:130 doi:10.1186/1471-2148-11-130