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Open Access Highly Accessed Research article

Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus

Pauline L Kamath1* and Wayne M Getz12

Author Affiliations

1 Department of Environmental Science, Policy and Management, University of California Berkeley, Berkeley, CA, USA

2 Department of Zoology and Entomology, Mammal Research Institute, University of Pretoria, Pretoria, South Africa

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BMC Evolutionary Biology 2011, 11:128  doi:10.1186/1471-2148-11-128

Published: 18 May 2011

Additional files

Additional file 1:

ELA-DRA and DQA allele sequences. Species, nomenclature and GenBank (NCBI, NIH) accession numbers listed for each allele. Allele sequences can be found at http://www.ncbi.nlm.nih.gov/genbank/ webcite.

Format: XLS Size: 28KB Download file

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Open Data

Additional file 2:

Nucleotide alignment of known ELA-DQA alleles identified in Equidae. Dots indicate identity to first sequence in alignment, Eqas-DQA*01. E. burchelli alleles are shown in gray. The thirteen novel E. burchelli alleles identified in this study (Eqbu-DQA*09 -*21) are highlighted in dark gray, whereas alleles discovered in previous studies are highlighted in light gray. One allele (Eqbu-DQA*21) has a frame-shift mutation (~) at position 176.

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Open Data

Additional file 3:

Nucleotide alignment of known ELA-DRA alleles identified in Equidae. Dots indicate identity to first sequence in alignment, Eqas-DRA*01. E. burchelli alleles are shown in gray. The five novel E. burchelli alleles identified in this study (Eqbu-DRA*07 -*11) are highlighted in dark gray, whereas alleles discovered in previous studies are highlighted in light gray.

Format: PDF Size: 39KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data