Figure showing TM structure in relation to overlaid DLP-SVM prediction. The figure shows TMHMM transmembrane predictions and DLP-SVM predictions for example sequences representing human asymmetric DMT families: NIPA1 (DUF803), SLC30A1 (Cation efflux), SLC39A1 (Zip). TMHMM (http://www.cbs.dtu.dk/services/TMHMM/ webcite) is used with default settings, and DLP-SVM is used with the settings presented in the methods section. The SVM peak values and SVM scales, projected on the TMHMM figure using a bold blue curve are as follows: 1.159 (-3 => 1.5), 2.287 (-3 => 3), 1.941 (-2.5 => 2.5). The presumed respective two domain structure is 4+5, 4+2, 3+5 TM (the red peaks represent TM helices).
Västermark et al. BMC Evolutionary Biology 2011 11:123 doi:10.1186/1471-2148-11-123