Table 1

The GenoPheno correlation for similar ethnic groups at similar regions

Population

Lactase persistence genotype data

Lactase persistence phenotype data

Genotype-phenotype correlation





Continent

Country

Population

N

Sum of LP-associated alleles frequency

Predicted LP freq.

Ref.

N

Pheno. Freq.

Testing method

Ref.

GenoPheno P-value

Genotype - phenotype quantitative difference





Africa

Nigeria

Yoruba

50

0.00

0.00

[18]

48

0.17

BG

[43]

0.5670

0.17

Africa

Senegal

Wolof

118

0.00

0.00

[24]

53

0.51

BG

[44]

<0.00005

0.51

Africa

Sudan

Beni Amer

162

0.26

0.45

[24]

40

0.88

BH

[45]

<0.00005

0.42

Africa

Uganda

Bantu

44

0.00

0.00

[8]

17

0.06

BG

[46]

0.7552

0.06

Asia

China

Kazakh

94

0.00

0.00

[47]

195

0.24

BH

[48]

0.0026

0.24

Asia

India

Indian

68

0.07

0.14

[7]

38

0.00

BIOPSY

[49]

0.0024

-0.14

Asia

Japan

Japanese

62

0.00

0.00

[18]

40

0.28

BG

[50]

0.0432

0.28

Asia

North India

Northern Indian

128

0.33

0.55

[7]

136

0.55

BG

[51,52]

1.0000

0.00

Asia

Russia

Komi

20

0.15

0.28

[23]

56

0.38

BG

[53]

0.9248

0.10

Europe

Finland

Finns

1876

0.58

0.82

[23]

638

0.83

BIOPSY

[54]

0.3686

0.01

Europe

Greece

Greek

100

0.09

0.17

[40]

200

0.25

BH

[55]

0.8136

0.08

Europe

Hungary

Hungarian

110

0.62

0.86

[56]

262

0.59

BH

[57]

<0.00005

-0.26

Europe

Ireland

Irish

65

0.95

1.00

[8]

50

0.96

BG

[58]

0.6014

-0.04

Europe

Italy

Sardinian

153

0.07

0.14

[40]

47

0.15

BH

[59]

0.5530

0.01

Europe

Italy

North Italian

28

0.36

0.59

[18]

208

0.49

BH

[60]

0.3348

-0.10

Europe

Italy

Central Italian

98

0.11

0.21

[40]

65

0.82

BG

[61]

<0.00005

0.61

Europe

Italy

Southern Italian

189

0.08

0.15

[40]

99

0.46

BH

[62]

<0.00005

0.31

Near/Middle East

Afghanistan

Tadjik

98

0.30

0.51

[7]

79

0.18

BG

[63]

<0.00005

-0.33

Near/Middle East

Afghanistan

Pashtu

16

0.10

0.19

[18]

71

0.21

BG

[63]

0.3588

0.02

Near/Middle East

Iran

Iranian

42

0.10

0.19

[23]

21

0.14

BG

[64]

0.4154

-0.05

Near/Middle East

Israel

Arabs

160

0.05

0.10

[24]

67

0.19

BG

[65]

0.8966

0.10

Near/Middle East

Jordan

Jordanian

112

0.11

0.20

[23]

162

0.76

BH

[66]

<0.00005

0.55

Near/Middle East

Pakistan

Balochi

50

0.00

0.00

[18]

32

0.38

BH

[67]

0.0036

0.38

Near/Middle East

Saudi Arabia

Bedouin

94

0.48

0.73

[23]

21

0.81

BH

[68]

0.5166

0.08

Near/Middle East

Turkey

Turks

98

0.03

0.06

[8]

126

0.30

BH

[69]

0.0076

0.24


GenoPheno was used to calculate the P-value for lack of correlation between the predicted phenotype (based on all 4 known LP-associated alleles) and the observed phenotype at locations where the ethnic groups were similar, and so expected to have a good genotype-phenotype correlation. Unlike figures 5 and 6, interpolation was not used here, but rather observed points analyses.

Itan et al. BMC Evolutionary Biology 2010 10:36   doi:10.1186/1471-2148-10-36

Open Data