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Table 1
The GenoPheno correlation for similar ethnic groups at similar regions
Population			Lactase persistence genotype data				Lactase persistence phenotype data				Genotype-phenotype correlation

Continent	Country	Population	N	Sum of LP-associated alleles frequency	Predicted LP freq.	Ref.	N	Pheno. Freq.	Testing method	Ref.	GenoPheno P-value	Genotype - phenotype quantitative difference

Africa	Nigeria	Yoruba	50	0.00	0.00	[18]	48	0.17	BG	[43]	0.5670	0.17
Africa	Senegal	Wolof	118	0.00	0.00	[24]	53	0.51	BG	[44]	<0.00005	0.51
Africa	Sudan	Beni Amer	162	0.26	0.45	[24]	40	0.88	BH	[45]	<0.00005	0.42
Africa	Uganda	Bantu	44	0.00	0.00	[8]	17	0.06	BG	[46]	0.7552	0.06
Asia	China	Kazakh	94	0.00	0.00	[47]	195	0.24	BH	[48]	0.0026	0.24
Asia	India	Indian	68	0.07	0.14	[7]	38	0.00	BIOPSY	[49]	0.0024	-0.14
Asia	Japan	Japanese	62	0.00	0.00	[18]	40	0.28	BG	[50]	0.0432	0.28
Asia	North India	Northern Indian	128	0.33	0.55	[7]	136	0.55	BG	[51,52]	1.0000	0.00
Asia	Russia	Komi	20	0.15	0.28	[23]	56	0.38	BG	[53]	0.9248	0.10
Europe	Finland	Finns	1876	0.58	0.82	[23]	638	0.83	BIOPSY	[54]	0.3686	0.01
Europe	Greece	Greek	100	0.09	0.17	[40]	200	0.25	BH	[55]	0.8136	0.08
Europe	Hungary	Hungarian	110	0.62	0.86	[56]	262	0.59	BH	[57]	<0.00005	-0.26
Europe	Ireland	Irish	65	0.95	1.00	[8]	50	0.96	BG	[58]	0.6014	-0.04
Europe	Italy	Sardinian	153	0.07	0.14	[40]	47	0.15	BH	[59]	0.5530	0.01
Europe	Italy	North Italian	28	0.36	0.59	[18]	208	0.49	BH	[60]	0.3348	-0.10
Europe	Italy	Central Italian	98	0.11	0.21	[40]	65	0.82	BG	[61]	<0.00005	0.61
Europe	Italy	Southern Italian	189	0.08	0.15	[40]	99	0.46	BH	[62]	<0.00005	0.31
Near/Middle East	Afghanistan	Tadjik	98	0.30	0.51	[7]	79	0.18	BG	[63]	<0.00005	-0.33
Near/Middle East	Afghanistan	Pashtu	16	0.10	0.19	[18]	71	0.21	BG	[63]	0.3588	0.02
Near/Middle East	Iran	Iranian	42	0.10	0.19	[23]	21	0.14	BG	[64]	0.4154	-0.05
Near/Middle East	Israel	Arabs	160	0.05	0.10	[24]	67	0.19	BG	[65]	0.8966	0.10
Near/Middle East	Jordan	Jordanian	112	0.11	0.20	[23]	162	0.76	BH	[66]	<0.00005	0.55
Near/Middle East	Pakistan	Balochi	50	0.00	0.00	[18]	32	0.38	BH	[67]	0.0036	0.38
Near/Middle East	Saudi Arabia	Bedouin	94	0.48	0.73	[23]	21	0.81	BH	[68]	0.5166	0.08
Near/Middle East	Turkey	Turks	98	0.03	0.06	[8]	126	0.30	BH	[69]	0.0076	0.24

GenoPheno was used to calculate the P-value for lack of correlation between the predicted phenotype (based on all 4 known LP-associated alleles) and the observed phenotype at locations where the ethnic groups were similar, and so expected to have a good genotype-phenotype correlation. Unlike figures 5 and 6, interpolation was not used here, but rather observed points analyses.
Itan et al. BMC Evolutionary Biology 2010 10:36 doi:10.1186/1471-2148-10-36

Table 1