Table 3

Conservation of five putative calcium coordinating residues in C2 domains.

Dysferlin

Paralogs

Orthologs

C2A

No

N/A

N/A

C2B

No

N/A

N/A

C2C

Yes

No

No

C2D

Yes

No

Yes (1,2)

C2E

Yes

Yes

Yes (1)

C2F

Yes

Yes

Yes(1)

Key: Yes indicates that all five aspartates are conserved; No indicates all five could not be identified; N/A indicates these domains were not tested for aspartates as the corresponding dysferlin C2 domains have not conserved the five aspartates; 1 indicates no conservation in Cele; 2 indicates no conservation in Dmel. Residues considered as having potential for calcium coordination include aspartic and glutamic acid.

Lek et al. BMC Evolutionary Biology 2010 10:231   doi:10.1186/1471-2148-10-231