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Open Access Research article

Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites

Lee R Hagey1*, Nicolas Vidal2, Alan F Hofmann1 and Matthew D Krasowski3*

Author Affiliations

1 Department of Medicine, University of California - San Diego, La Jolla, CA, USA

2 Département Systématique et Evolution, Muséum National d'Histoire Naturelle, Paris, France

3 Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA

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BMC Evolutionary Biology 2010, 10:133  doi:10.1186/1471-2148-10-133

Published: 6 May 2010

Additional files

Additional file 1:

Bile salts of reptiles. Table contains data on the bile salts of all reptiles analyzed, with bile salt profiles color-coded by bile salt class.

Format: PDF Size: 174KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Bile salts of mammals. Table contains data on the bile salts of all mammals analyzed, with bile salt profiles color-coded by bile salt class.

Format: PDF Size: 223KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Annotated bile salt profiles of reptiles and mammals. Examples of bile salt profiles (annotated ESI/MS/MS and GC/MS spectra) for reptiles and mammals are included.

Format: PDF Size: 2.2MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Bile salt synthetic enzymes. Excel spreadsheet contains the accession numbers for putative orthologs to the enzymes involved in bile acid biosynthesis in humans. For genes where reliable full-length sequences are available, the percent identity of the amino acid.

Format: XLS Size: 92KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

Model animals that may provide key insight into bile salt biosynthesis. Table compares and contrasts differences of bile salt enzymes between 5 model species that have interesting bile salt profiles.

Format: PDF Size: 43KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data