Evaluating uncertain gene variants in the clinic

A new method compares computer-based predictions of missense variants of uncertain significance and provides a visualization tool to aid clinical decision making.

H3K4me3 represses non-CpG island genes

Epigenetic mark H3K4me3 is demonstrated to protect both CpG-island and non-CpG island start sites in colon cancer from DNA methylation, suggesting similar mechanisms in both cases.

Dynamics of intracellular antiviral responses

A number of proteins are now known to sense viral infection in cells and signal antiviral responses. Studies by Damien Arnoult and colleagues suggest that the interferon response involves the sequential assembly and proteasomal dissolution of a signalling complex at the mitochondrial surface.

Finding the right omega 3/6 balance

Overabundance of omega 6 is associated with breast cancer and cardiovascular disorders. This nutritional food score identifies foods with optimum omega 3/6 balance, aiding nutritional decision-making.

Amyloid β overlap in PA and AD

Extensive overlapping between amyloid β (Aβ) levels found in pathological ageing (PA) and Alzheimer's disease (AD) brains indicates that PA represents a prodromal stage of AD or resistance to toxic effects of Aβ.