Representative striping patterns in corneal epithelia of XLacZ+/- mosaic mice. Intact eyes from 3–52-week old XLacZ+/- mice were stained for β-gal reporter activity. A: 3-weeks; B: 6-weeks; C: 8-weeks; D: 10-weeks; E: 15-weeks; F: 20-weeks; G: 26-weeks with an anticlockwise whorl; H: 39-weeks exhibiting a midline; I: 52-weeks with a clockwise whorl. J: Disrupted striping patterns in a wild-type eye appear to form a double whorling pattern. K: Some β-gal-positive stripes appear paler than others (white arrows). L: Section through a light blue and a dark blue stripe either side of a white stripe. M: Section through adjacent light and dark blue stripes. Scale bars in A-K = 1 mm. Scale bars in L-M = 100 μm.
Mort et al. BMC Developmental Biology 2009 9:4 doi:10.1186/1471-213X-9-4