Research article
Mosaic analysis of stem cell function and wound healing in the mouse corneal epithelium
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* Corresponding author: John D West john.west@ed.ac.uk
1 Division of Reproductive and Developmental Sciences, Genes and Development Group, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
2 MRC Human Genetics Unit, Crewe Road, Edinburgh, EH4 2XU, UK
3 Clinical Biochemistry Section, Division of Reproductive & Developmental Sciences, University of Edinburgh, Centre for Reproductive Biology, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
BMC Developmental Biology 2009, 9:4 doi:10.1186/1471-213X-9-4
Published: 7 January 2009Additional files
Time-lapse confocal microscopy of healing of a 1 mm diameter central wound in a PAX6-GFP mosaic corneal epithelium. Time-lapse video showing the complete healing of a central wound in the corneal epithelium between 5.25 and 18.75 hours post wounding. At 18.75 hours the wound appears completely healed and stripes extend to the centre of the previously wounded region.
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Time-lapse confocal microscopy of healing of a 1 mm diameter peripheral wound in a PAX6-GFP mosaic corneal epithelium. Time-lapse video showing incomplete healing of a peripheral wound in the corneal epithelium between 5.25 and 18.75 hours post wounding. At 18.75 hours the wound is only partially healed, stripes extend towards the centre of the previously wounded region.
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Additional file 3:
The effects of age on mean corrected stripe number in the corneal epithelium of X-inactivation mosaic mice.
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Additional file 4:
Comparisons of corneal epithelial stripe numbers in different regions (at 23–24 weeks).
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